This agent-based model (ABM) simulates cellular behaviors following volumetric muscle loss (VML) injury to predict the tissue remodeling response. The simulation focuses on the dynamics of fibroblasts and satellite stem cells and incorporates the behaviors and interactions of muscle fibers, ECM, growth factors and pro-inflammatory and anti-inflammatory macrophages. The model has the ability to simulate the tissue regeneration following an unrepaired VML injury, an injury treated with decellularized ECM, or an injury treated with minced muscle graft.

The project includes source code for the ABM. The model was built in Repast, a Java based modeling platform.