The goal of this project is to establish a computational modeling and simulation framework where an investigator can explore the importance of different mechanical variables on pressure ulcer formation and can evaluate isolated or combined effects of interventions on relative risk of pressure ulcer development. A finite element representation will incorporate the anatomy of an at-risk region, i.e. a bony prominence with multiple tissue layers, and also the deformation characteristics of the tissue layer and support surfaces. Given the loading on the region, simulations will predict internal and external mechanical variables that can be associated with pressure ulcer risk.